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Research Interests:
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Circulating Tumor Cells for Cancer Diagnosis and Prognosis
Early detection of cancer and monitoring of cancer therapy are critical in
increasing the chances of survival. The CBRP is developing and testing an
innovative instrument and method to greatly improve both the early detection of
breast cancer and help improve disease progression monitoring.
Metastasis, the major cause of mortality in patients with cancer, is caused
by tumor cells that escape from the primary tumor into the bloodstream and
travel through the circulation to distant sites where they develop into
secondary tumors. Although these
circulating tumor cells (CTCs) provide a link between the primary tumor and
metastatic sites, the factors involved in circulating tumor cell survival in the
blood circulation and eventual metastases are not well understood.
CTCs exist in the peripheral blood of cancer patients in low concentrations,
making their isolation and identification a difficult task. Our laboratory has
developed a reliable way to detect and to characterize CTCs isolated from the
blood of cancer patients. We currently have multiple on-going clinical trials
aimed to investigate the clinical utility of CTCs.
To read more please visit
cancer.scripps.edu
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JCIMPT: JCSG Center for Innovative Membrane Protein Technologies:
The mission of JCIMPT is to develop and disseminate methods and technolgies
for structure-grade production of integral membrane proteins. Miniaturization
and automation are major components in the systematic investigation of membrane
proteins and in the development of novel genetically engineered expression
systems and sample preparation technologies. The structure of the JCIMPT
includes three primary projects: Membrane Protein Expression; Membrane Protein
Stablization; and Membrane Protein Biophysical Analysis.
To read more please visit
jcimpt.scripps.edu
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C-ME: Collaborative Molecular
Modelling Environment:
In collaboration with Interknowlogy, LLC (Carlsbad, CA) and support from
Microsoft, Inc., we have developed and are further improving a software client
named C-ME to enable improved collaboration among scientists. C-ME uses the
latest Microsoft technologies, Vista, Office 2007 and Sharepoint 2007.
To read more please visit
c-me.scripps.edu
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